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tobacco companies started researching nicotine analogs in the 1970s in anticipation of future regulations that could reduce how much nicotine would be allowed in their products, according to a study of industry documents

PMID 15217537

Smoking can cause: facial wrinkles, especially around the lips baggy eyelids uneven skin coloring, such as a yellow or gray tone dry, coarse skin temporary yellowing of the fingers and fingernails Smoking reduces how quickly skin repairs itself, increases the risk of skin infections, and increases the severity of skin conditions, including psoriasis

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